![]() Dose: Vitamin K 1 should be administered at 3 to 5 mg/kg PO divided Q 12 H with a fatty meal to enhance absorption. Study with Quizlet and memorize flashcards containing terms like 97) Which antidote would the nurse anticipate administering to a client whose laboratory report establishes a warfarin overdose Physostigmine Vitamin K Iron dextran Protamine sulfate, 115) Which response to fludrocortisone will the nurse teach a client with adrenal insufficiency to report Select all that apply. Serious bleeding manifestations are common. Begin prophylactic vitamin K 1 therapy or Monitor PT and only administer vitamin K 1 if PT becomes elevated (see How Vitamin K 1 Works). ![]() Pentoxifylline acts on red blood cells (RBCs) to reduce their viscosity and increase their flexibility to allow them to enter partially occluded vessels. Severe deficiency of vitamin Kdependent proteins in patients not maintained on vitamin K antagonists is most commonly associated with poisoning by or surreptitious ingestion of warfarin, warfarin-like anticoagulants, or potent rodenticides (superwarfarins), such as brodifacoum. Vitamin C is found in tomatoes, strawberries, and broccoli. Vitamin C is found in animal sources such as dairy products and meat. Vitamin C is important for tissue repair. Finally, the chemistry developed here has been used to define the active site of vitamin K hydroquinone as the carbon-carbon bond adjacent to the methyl group. Study with Quizlet and memorize flashcards containing terms like Naloxone (Narcan), vitamin K, protamine sulfate and more. Vitamin K is the antidote for warfarin (Coumadin) overdose and its administration is warranted with an international normalized ratio (INR) of 7. Vitamin C is important in the maintenance of bone, teeth, and capillaries. The new model postulates a dioxetane intermediate that explains the presence of a second atom of 18O (from 18O2) incorporated into vitamin K oxide in the course of the enzymatic carboxylation. The model hypothesis is also supported by the mechanism of inhibition of the carboxylase by HCN, which acts as an acid-base inhibitor rather than a metal-complexing inhibitor. The model comprises an oxygenation that is coupled to carbon-carbon bond formation, as is the oxygenation of vitamin K hydroquinone to vitamin K oxide. ![]() This is the essential step leading to carboxylation and activation of the blood-clotting proteins. The mechanism of action of vitamin K is discussed in terms of a new carbanion model that mimics the proton abstraction from the gamma position of protein-bound glutamate. ![]()
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